Download or read book Computational Investigation of Gene Regulation: From DNA Binding to Network Function written by Mark Maienschein-Cline and published by . This book was released on 2012 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gene expression is central to the identity and behavior of a cell. Expression is controlled at every stage of transcription and translation, but the first step is transcriptional initiation by RNA polymerase. A vast repertoire of special proteins, transcription factors (TFs), interact with DNA, RNA polymerase, and other proteins to regulate transcription. The gene regulatory networks that arise from TF-TF regulations form the fundamental basis for cellular behavior.