Download or read book Cerebrovascular Pathology in Alzheimer's Disease written by Jack C. De La Torre and published by . This book was released on 1997 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt: The pathogenesis and progression of Alzheimer's disease is examined from the less-usual vantage point of the dysfunctional cerebrovasculature on amyloid formation, loss of neuronal homeostasis, synaptic changes, metabolic compromise, and cognitive decline. The book explores whether the cerebrovascular changes precede or follow clinical onset of the disease and the extent to which the pathological changes found in the brains of patients with Alzheimer's disease are related to cerebral blood flow, perfusion, and blood-brain barrier dysfunction.