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Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 452 Chronic Toxicity Studies

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OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 452: Chronic Toxicity Studies

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 452: Chronic Toxicity Studies
Author :
Publisher : OECD Publishing
Total Pages : 18
Release :
ISBN-10 : 9789264071209
ISBN-13 : 9264071202
Rating : 4/5 (202 Downloads)
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Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 452: Chronic Toxicity Studies by : OECD

Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 452: Chronic Toxicity Studies written by OECD and published by OECD Publishing. This book was released on 2018-06-27 with total page 18 pages. Available in PDF, EPUB and Kindle. Book excerpt: The objective of these chronic toxicity studies is to characterize the profile of a substance in a mammalian species (primarily rodents) following prolonged and repeated exposure. The Test Guideline focuses on rodents and oral administration. Both ...


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OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 452: Chronic Toxicity Studies
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The objective of these chronic toxicity studies is to characterize the profile of a substance in a mammalian species (primarily rodents) following prolonged and
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The objective of a combined chronic toxicity/carcinogenicity study is to identify carcinogenic and the majority of chronic effects, and to determine dose-respon
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A principle of the method is that in the main study only moderately toxic doses are used, and the administration of doses that are expected to be lethal should
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The objective of a long-term carcinogenicity study is to observe test animals for a major portion of their life span for the development of neoplastic lesions d